The PRO14 returned last weekend following a two-week hiatus for the Six Nations with wins for all four Irish provinces.
Jack Carty will start on the bench for Ireland's Guinness PRO14 clash against Italy after Joey Carbery was ruled out through injury.
Ronan Kelleher will make his Leinster debut in the Guinness PRO14 against the Southern Kings on Friday night.
There are six changes to the Munster starting XV that defeated Southern Kings for Friday's Guinness PRO14 clash with Ospreys.
Tyler Bleyendaal, Ciaran Parker and Alby Mathewson have all signed contract extensions with Munster.