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Paul McShane scored his first FA Cup goal in nine years, as Championship side Reading beat West Brom 3-1 at the Madejski Stadium to progress to the sixth round.
Darren Fletcher gave the Baggies the lead ten minutes into the second half with a shot from the edge of the Reading area, but Ireland international McShane levelled five minutes later for the 2015 FA Cup semi-finalists with an emphatic header from Oliver Norwood's free-kick.
On-loan Chelsea defender Michael Hector put the home side ahead on 72 minutes from another Norwood cross, then Lucas Piazon struck deep into injury-time as Brian McDermott's side reached the last eight in the FA Cup for the second consecutive season.
The afternoon ended on an even sourer note for West Brom midfielder Chris Brunt, who struck by a coin by one of his own supporters after the final whistle.
In the afternoon's other FA Cup tie, Premier League Watford beat Championship side Leeds United 1-0 at Vicarage Road to progress to the last eight for the first time since 2007.
The only goal of the match came after 52 minutes, when Leeds defender Scott Wootton diverted Ben Watson's cross into his own net when trying to cushion the ball back to his goalkeeper Marco Silvestri.
In the day's earlier fixture, holders Arsenal and Hull City played out a goalless draw in the FA Cup fifth round tie at the Emirates.
The Tigers' Swiss international goalkeeper Eldin Jakupovic repelled Arsene Wenger's side almost single-handedly, his best save a brilliant tip on to the post from Joel Campbell's thunderous 53rd minute free-kick.
In the day’s late clash, Everton booked their place in the last eight with a 2-0 win away to Bournemouth.
Second-half goals from Ross Barkley and Romelu Lukaku - the England man scored with a deflected effort and the Belgian striker finished from close range - ensured the progress of Roberto Martinez and his troops.
The Cherries will be upset with the defeat, having seen a first-half Charlie Daniels penalty kick saved by Joel Robles, before missing several opportunities when a solitary goal behind.