George Ford and Owen Farrell have both been named in the England team to face Ireland at Twickenham on Saturday.
It will be the first time in over a year that the pair will start an international together. Ford and Farrell formed a successful partnership in the early years under Jones, before Farrell switched to fly-half last year.
The Saracens man will captain the side from inside centre, with Manu Tuilagi named at thirteen. It is the first time that they have featured in midfield together in a test match.
Flankers Sam Underhill and Tom Curry are both fit and are named in the back row.
Elliot Daly continues at full-back, with Ben Youngs partnering club-mate Ford in the half-backs.
Joe Marler makes a first start since coming out of international retirement to partner Jamie George and Kyle Sinckler in the front row, with Billy Vunipola named at number eight and brother Mako on the bench after a long injury lay-off.
"This weekend we will be looking to gain more match fitness and test different sorts of game strategies," head coach Eddie Jones said.
“The players have come back in a very good physical and mental state and we have had a good preparation this week.
"We purposefully made the week short looking ahead to the World Cup where this might happen beyond our control.
"It is the third of four games for us and come September 8th, when we get on the plane, we want to be ready to go. This is another step forward for us."
England (v Ireland): Daly, Cokanasiga, Tuilagi, Farrell, May, Ford, Youngs, Marler, George, Sinckler, Itoje, Kruis, Curry, Underhill, B Vunipola.
Replacements: Cowan-Dickie, M Vunipola, Cole, Lawes, Wilson, Heinz, Francis, Joseph.
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