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Leicester will begin the defence of their Premier League title away to newly promoted Hull City but the big game of the opening weekend sees Arsenal host Liverpool at the Emirates Stadium.
The first games of the 2016-17 season are scheduled to take place over the weekend of August 13-14 and Claudio Ranieri will be hoping the Foxes can make a winning start to their campaign after defying the odds to lift the Premier League trophy last season.
Manchester City, Manchester United, Chelsea, Everton and Southampton will all start the season with new managers and there are some intriguing ties for the clubs with Pep Guardiola facing Sunderland at the Etihad Stadium.
Jose Mourinho's first Premier League outing as United manager will see him take his side to Bournemouth, while Antonio Conte's Chelsea face West Ham in a tricky start to the season.
Former Southampton managers Ronald Koeman and Mauricio Pochettino will square off on the first weekend when Everton host Tottenham as their former club open at home to Watford.
Newly-promoted Burnley host Swansea with Middlesbrough welcoming Stoke and West Brom travelling to Crystal Palace.
Arsenal face a tough start to the season with Liverpool first up before a trip to defending champions Leicester a week later.
After the visit to the Emirates, Jurgen Klopp's Liverpool will welcome Burnley to Anfield on August 20, before facing Tottenham Leicester and Chelsea before the end of September.
The first Manchester derby between Mourinho and Guardiola is scheduled for September 10 at Old Trafford, while the United manager will return to Stamford Bridge on October 29, just a week after a daunting trip to Anfield.
Teams will play three games over the busy Christmas period with Liverpool's meeting with Manchester City on New Year's Eve the standout fixture.
On the final day of the season, Arsenal host Everton, Sunderland travel to Chelsea, United entertain Crystal Palace and City make the trip to Watford.
Premier League fixtues August 13-14:
Bournemouth v Manchester United
Arsenal v Liverpool
Burnley v Swansea City
Chelsea v West Ham United
Crystal Palace v West Bromwich Albion
Everton v Tottenham Hotspur
Hull City v Leicester City
Manchester City v Sunderland
Middlesbrough v Stoke City
Southampton v Watford
Arsenal v West Bromwich Albion
Burnley v Middlesbrough
Chelsea v Bournemouth
Hull City v Manchester City
Leicester City v Everton
Liverpool v Stoke City
Manchester United v Sunderland
Southampton v Tottenham Hotspur
Swansea City v West Ham United
Watford v Crystal Palace
Arsenal v Crystal Palace
Burnley v Sunderland
Chelsea v Stoke City
Hull City v Everton
Leicester City v West Ham United
Liverpool v Manchester City
Manchester United v Middlesbrough
Southampton v West Bromwich Albion
Swansea City v Bournemouth
Watford v Tottenham Hotspur
Bournemouth v Arsenal
Crystal Palace v Swansea City
Everton v Southampton
Manchester City v Burnley
Middlesbrough v Leicester City
Stoke City v Watford
Sunderland v Liverpool
Tottenham Hotspur v Chelsea
West Bromwich Albion v Hull City
West Ham United v Manchester United
Arsenal v Everton
Burnley v West Ham United
Chelsea v Sunderland
Hull City v Tottenham Hotspur
Leicester City v Bournemouth
Liverpool v Middlesbrough
Manchester United v Crystal Palace
Southampton v Stoke City
Swansea City v West Bromwich Albion
Watford v Manchester City