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Trainer Mick Channon hopes Harlequeen can finally break her season's duck at Cork on Tuesday.
The daughter of Canford Cliffs drops down to Grade Three level in the Irish Stallion Farms EBF Give Thanks Stakes, where she will take on the Aidan O'Brien-trained Somehow, who is fitted with a visor for the first time, and Best In The World.
O'Brien's son Joseph sends out Arya Tara, who steps up in grade after four consecutive victories, while Dermot Weld's Munster Oaks runner-up Shamreen also features in a nine-strong field.
Although Harlequeen is without a win this season, she has finished fourth in the Musidora Stakes at York and third in both the Investec Oaks at Epsom and the Irish Oaks at the Curragh.
"She looks to have a great chance, but it's never easy when you're up against the likes of Aidan O'Brien and Dermot Weld. It's not a gimme, that's for sure," Channon said.
"She's in very good form and we've been very happy with her since the [Irish] Oaks.
"We want to get her back winning again before hopefully stepping back up for something more sexy later on.
"She's tough enough to go back to Ireland again, so fingers crossed."