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Richie Hogan will play no part in Kilkenny's Leinster SHC semi-final against Dublin on Saturday.
Hogan broke a bone in his hand while playing for his club Danesfort last month and the former Hurler of the Year has failed to recover in time to feature in the O'Moore Park clash.
Captain Shane Prendergast also misses out but Eoin Larkin returns to the side following a tour of duty in Syria.
Conor Fogarty has been passed fit to take his place in midfield, while Michael and Colin Fennelly have been included in attack.
Kilkenny (SH v Dublin): E Murphy; P Murphy, J Holden, J Tyrrell; P Walsh, K Joyce, C Buckley; C Fogarty, L Ryan; W Walsh, M Fennelly, TJ Reid; J Farrell, C Fennelly, E Larkin.
Meath manager Mick O'Dowd has handed debuts to four players ahead of Sunday's Leinster SFC quarter-final against Louth.
Cillian O'Sullivan will make his championship bow at left half-forward as Darragh Smith and Alan Douglas start at wing-back. Cian O'Brien gets the nod at right half-forward.
Donal Keogan takes over at full-back for the injured Conor McGill.
Meath (SF v Louth): P O'Rourke; D Tobin, D Keogan, M Burke; D Smyth, P Harnan, A Douglas; H Rooney, A Tormey; C O'Brien, G Reilly, C O'Sullivan; E Wallace, D McDonagh, M Newman.
Louth have kept faith with the same team that defeated Carlow in the first round for the clash at Parnell Park.
Louth (SF v Meath): C Lynch; P Rath, P Reilly, K Toner; D Maguire, D McMahon, A Williams; J Stewart, J Califf; D Byrne, J McEneaney, C McKeever; B Duffy, C Grimes, R Burns
There is just one change to the Roscommon team for Sunday's Connacht SFC semi-final against Sligo.
Joint-managers Fergal O'Donnell and Kevin McStay have included Senan Kilbride at right corner-forward for the Hyde Park clash with Diarmuid Murtagh missing out through injury.
Roscommon (SF v Sligo): G Claffey; S McDermott, N Collins, N McInerney; J McManus, S Purcell, D Murray; N Daly, J McDermott; F Cregg, C Murtagh, C Devaney; S Kilbride, C Cregg, D Shine.
Meanwhile, Brian Egan will make his championship debut for the Yeats County after being named at left corner-forward for the game.
Mark Breheny captains the side from centre-forward as Adrian McIntyre makes his championship return for Sligo after missing the 2015 campaign.
Sligo (SF v Roscommon): A Devaney; D Maye, K McDonnell, E Flanagan; K Cawley, A McIntyre, B Egan; N Murphy, C Breheny; N Ewing, M Breheny, C Harrison; A Marren, P Hughes, B Egan.