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Marcus Rashford and Marouane Fellaini netted, as 11-time holders Manchester United beat West Ham 2-1 in the FA Cup quarter-final replay at Upton Park.
James Tomkins netted a 77th minute consolation to set up a rip-roaring finale in the last FA Cup tie at the Boleyn Ground, but Slaven Bilic's side were unable to beat the brilliant United goalkeeper David de Gea a second time in the closing stages.
United will now meet Roberto Martinez's Everton in the FA Cup semi-final at Wembley on Saturday, 23 April.
Louis van Gaal's visitors made the running in the first half, with West Ham's Republic of Ireland international goalkeeper Darren Randolph making two fine saves as the Bray man looks to cement his place as Martin O'Neill's first choice for Euro 2016.
His first came in the 18th minute when he tipped over a deflected Fellaini shot, while his second was a mini-masterclass in goalkeeping technique as he stayed tall when Jesse Lingard bore down on the West Ham goal, before reacting quickly to the United winger's low shot to make a sharp stop with his left foot.
West Ham, so vibrant on Saturday in the Premier League 3-3 draw with Arsenal, were laboured and off the pace in the opening 45 minutes, with playmaker Dimitri Payet for once subdued.
And it was United, playing the flowing football their fans have been craving all season, who took the lead on 54 minutes when Rashford brilliantly curled an effort beyond Randolph from Martial's pass after Michail Antonio had given the ball away cheaply near the halfway line.
And the much-maligned Fellaini doubled the score 12 minutes later, diverting Martial's drive from the left-hand edge of the six-yard box past Randolph with his knee.
United goalkeeper de Gea made a brilliant stop to keep out Antonio's near-post effort on 77 minutes, only to concede seconds later from the corner, as Tomkins bravely hurled himself at Andy Carroll's header back across goal to halve the deficit.
The Hammers resorted to the tried-and-tested tactic of swinging crosses up to the big man in their quest for an equaliser, and Carroll went close with a header from Aaron Cresswell centre, then de Gea made a brilliant double block to deny Cheikhou Kouyate and Carroll before a linesman's flag ruled out a third shot from the Senegal striker.
There was a late outing from the substitutes' bench for Wayne Rooney, making his first appearance since suffering knee ligament damage against Sunderland on 13 February.
The five-time Premier League, two-time League Cup and 2008 Champions League winner has famously never won the FA Cup, joining the Old Trafford club the summer after their last win in 2004, and the United and England captain's smile at the final whistle was a big as any in the 5,000-strong United end in the 33,505 crowd.