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Goals from Pione Sisto and Paul Onuachu helped FC Midtjylland come from a goal down to beat Manchester United 2-1 in the Europa League last-32 first-leg in Denmark.
In what was a thoroughly entertaining game, United took the lead through Memphis Depay after 37 minutes.
But they were unable to build on this and went in level at the break. And it was the hosts who looked the better side after the break as they grabbed a winner to heap more pressure on Louis van Gaal.
United started on the back-foot but they weathered an early storm and created the first real chance of the night after eight minutes.
Jesse Lingard broke quickly and played a great ball into the path of Memphis Depay but his effort was well blocked by Kian Hansen.
From the resulting corner, Daley Blind found Juan Mata at the near post but his strike was batted away by Mikkel Andersen in the Midtjylland goal.
The game was wide open from the off and it was the hosts who threatened next. From a corner, Hansen rose highest and powered a header goalwards but his header was superbly saved by Sergio Romero.
Romero was called into action again ten minutes before the break when United left themselves open at the back.
A long ball forward was controlled by Vaclav Kadlec who raced clear and through one on one but he panicked and shot straight at Romero.
This saved proved all the more important just 56 seconds later when the visitors took the lead. Memphis Depay pounced on a low cross into the area and scuffed home to put United 1-0.
This lead didn’t last long, though, as Midtjylland equalised on the stroke of half-time.
Michael Carrick played a slack pass across the back that was intercepted by Pione Sisto and the midfielder fired a powerful strike past Romeroo, via a deflection off Chris Smalling, to send the sides in level at the break.
The second half stared much like the first had finished with both sides on the attack.
And it was United who were first to threaten after five minutes when Ander Herrera found Lingard at the back-post, but his half-volley rattled the crossbar.
Midtjylland, though, were right in the tie and they went close again after an hour.
Paul Onuachu met a cross from the right and produced a fine header that looked destined for the top corner but Romero was on hand again with another sensational save to keep it at 1-1.
However, there was nothing the keeper could do 13 minutes from time when Onuachu out muscled Juan Mata on the edge of the box and slotted past Romero to make it 2-1 to the hosts.
And it was the home side who looked the more likely to extend their lead in the final ten minutes as they created a host of chances, but they were unable to find a third as United held on for an embarrassing 2-1 defeat.
In Florence, Spurs continued their fine recent form as they
made it eight games without defeat with a 1-1 draw against Fiorentina in Florence.
After a fairly even opening half an hour, the visitors began to dominate and they took the lead from the penalty spot after 37 minutes.
Ben Davies burst into the area, before being fouled by Nenad Tomovic and the referee correctly pointed to the penalty spot.
Nacer Chadli stepped up and calmly slotted home to send his side in 1-0 up at half-time.
Spurs started the second half well as they pushed for a second, but they were undone by a deflected strike after an hour.
Federico Bernardeschi received the ball 30 yards from goal and hit a rasping strike that deflected off Ryan Mason and flew into the top corner to make it 1-1.
The hosts grew into the game after this as they threw men forward in search of a winner, but Spurs stood firm and held on to secure a slight advantage ahead of the second leg.