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Saturday's Calvin Houghland Iroquois Hurdle was "one race too many" for both Shaneshill and Nichols Canyon, according to trainer Willie Mullins.
The charges, owned by Graham Wylie, finished second and third respectively in the Grade 1 battle at Percy Warner Park in Nashville, Tennessee.
With Danny Mullins on board, Shaneshill finished powerfully but was unable to defeat the victorious Rawnaq, while Nichols Canyon and Ruby Walsh came home three lengths adrift.
"Nichols Canyon did not jump that well and maybe wasn't best suited to going left-handed, while Shaneshill ran a big race," said the trainer, who went on to reference the effects of a long season.
"However, for both horses this was probably one race too many, but we look forward to returning next year."
Irvin Naylor, owner of Rawnaq, is eyeing next year's Cheltenham Festival for his victorious horse.
"There were so many good horses in the race, and our jockey (Jack Doyle) rode a superb race. He was always in the right place at the right time.
"The horse jumped flawlessly.
"It all came together for this most important race. Rawnaq gave it all, and you cannot ask for more of a horse than to give his all.
"He is the best, and I think he will represent the US well at Cheltenham. I look forward to going forward with this challenge."