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Munster suffered the fifth defeat of the Pro 12 campaign, losing 21-17 to Ospreys at Musgrave Park on Sunday.
Anthony Foley's side are now seven points off a Pro12 play-off spot following the defeat, their first at the Cork stadium for three years.
Munster had won 12 games in succession at Musgrave Park since a January 2013 defeat to Cardiff Blues before Sunday's defeat.
Duncan Williams opened the scoring for Munster, and although Ospreys hit back through Sam Davies, Francis Saili went over for his first try in 15 appearances to make it 12-7 to the home side.
Williams kicked over a penalty to reduce Munster's lead at the half-time break to 12-10, but the hosts Munster extended their lead when Robin Copeland went over for his seventh try for the province.
Davies reduced the deficit to four points when he kicked over a penalty to make it 17-13 with a penalty and then the Welsh side took for the first time when Owen Watkin went in at the left corner.
Man-of-the-match Davies then kicked his third penalty of the match two minutes from time to complete the four-point win for Steve Tandy's side.