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Sean O'Brien is expected to undergo surgery on a persistent hamstring injury and will miss Ireland's summer tour to South Africa.
O'Brien has not played since he was injured just 20 minutes into Ireland's RBS Six Nations defeat to France in February.
He came close to making his return in the latter stages of the Guinness PRO12 season only to suffer a serious setback and he is likely to require surgery, which will keep him out for a 'considerable period'.
"Sean O’Brien is going to see a specialist in the UK again tomorrow, so the likelihood is he’s going to have surgery on that hamstring, which would rule him out for a considerable period. I’m not sure how long, we’ll get the update after the procedure," Leinster head coach Leo Cullen reported on Thursday.
"He had the high hamstring tear and there were still fibres intact. Guys have been able to rehab back without surgery from similar injuries.
"Other guys have had that complete rupture where they’ve gone for the surgical route straight away. It was slower to heal than we would have liked, he was getting close and putting in his rehab, but just broke down at that stage.
"We sought out a few opinions at that stage and he’s going down the surgical route now which is frustrating for all."
Cian Healy is also likely to miss Ireland's tour to South Africa as he continues to be monitored following a series of niggling injuries this season.
“It’s unlikely Cian will feature for us this season,” Cullen explained.
"He’s just being assessed all the time. Apologies if that comes across as vague, but the reality is that we’re just trying to put a really good plan in place for him so we’re assessing him on a very regular basis.
"He had a surgical procedure this time last year on his neck. It’s been slow coming back when he’s had a little bit of nerve damage. He had a procedure done to repair those nerves so it’s taken time to come back.
"To complicate matters further, he’s also been carrying an issue with his knee but he’s on a good course of action for that. We’re not trying to be vague, but unfortunately it does sometimes appear that way."