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Manuel Pellegrini could be without Yaya Toure for the Champions League semi-final second-leg tie with Real Madrid.
Toure missed the first leg after picking up a thigh injury in the 4-0 win over Stoke and will sit out the weekend's game against Southampton as he works on his fitness.
The Ivorian will be assessed over the weekend before Pellegrini makes a decision on his availability for the trip to the Santiago Bernabeu.
"Yaya starts working today - we'll see the way he improves through the weekend; we'll see if he's fit on Wednesday. He has some options," Pellegrini told his weekly press conference.
David Silva will definitely miss the second leg as a result of the hamstring injury he picked up in the 0-0 draw at the Etihad Stadium.
"David has a small hamstring injury so he will not be fit for this week. He needs two or three weeks to recover," Pellegrini confirmed.
Pellegrini delivered an upbeat report on the fitness of Samir Nasri and Raheem Sterling ahead of the trip to Southampton.
"All of the other players are fit," Pellegrini added. "Samir worked this week without a problem - he will be in the squad list for Sunday.
"Raheem is just coming back from an important muscle injury which is why he's playing just some minutes. If we have the best of him for the next four or five games, we'll be happy."