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Jamie Vardy grabbed the headlines as Leicester City beat Liverpool 2-0 to stay three points clear at the top of the Premier League.
The 29-year-old opened the scoring with a stunning 25-yard strike over goalkeeper Simon Mignolet from Riyad Mahrez's long ball forward.
Vardy then sealed the win in front of the watching England boss Roy Hodgson sealed the victory when he forced home Shinji Okazaki's deflected shot from close range.
The Foxes were much the better side and Mignolet also pushed an Okazaki header onto the bar in the first half.
Manchester City earned a hard-fought victory at Sunderland to remain hot on the heels of Leicester.
Sergio Aguero's cool finish with the outside of his left foot proved the difference but the hosts will consider themselves unlucky not to have grabbed a point.
Billy Jones hit the post for the Mackems while he also forced Joe Hart into making a sharp save.
Arsenal fell five points off the pace, dropping to fourth in the Premier League table after they were held to a goalless draw by Southampton.
The Gunners had numerous chances but were unable to break down a resolute Saints defence, who have now gone four games without being breached by an opponent.
Fraser Forster was superb in goals, making a series of impressive saves, including denying Mesut Ozil on more than one occasion.
Arsenal are now winless in four league games and drop below north London rivals Spurs on goal difference.
Harry Kane scored twice as Tottenham beat Norwich City 3-0 at Carrow Road.
Dele Alli tapped home after two minutes to give Mauricio Pochettino 's side the lead before Kane stroked in the second from the spot after Alli was fouled in trying to follow up Kane's saved shot.
The England striker then grabbed his second of the night from just inside the penalty box after Christian Eriksen had dispossessed Martin Olsson and set him up.
Manchester United scored two first-half goals to cruise past a disappointing Stoke City by 3-0 at Old Trafford.
Louis Van Gaal's side had gone 11 league matches without scoring in the opening 45 minutes at home, until Jesse Lingard headed home at the back post from Cameron Borthwick-Jackson's cross from the left.
Anthony Martial curled a second on 23 minutes, a wonderful finish into the top corner to finish a sharp attacking move reminiscent of the United of old.
Wayne Rooney swept home a third not long after the break while substitute Memphis Depay struck narrowly over the crossbar late on as the Potters offered no hint at getting back into the game.
West Ham notched up their fourth win in six league games to stay sixth in the table with victory over 10-man Aston Villa.
Jordan Ayew was dismissed on 17 minutes for elbowing Aaron Cresswell and after West Ham had taken a grip on the game, their pressure finally told when Michail Antonio headed home Mark Noble's cross.
Cheikhou Kouyate doubled the lead late on with a clinical finish to round off a rapid counter-attack.
Bournemouth came from behind to make it five defeats on-the-spin for Crystal Palace.
Scott Dann turned in Wilfried Zaha's cross to put the Eagles ahead but just six minutes later Marc Pugh equalised for the visitors with a low shot.
Benik Afobe headed in the winner after Wayne Hennessey had parried Matt Ritchie's shot.
Salomon Rondon's rescued a point for West Brom as he scored in injury time to deny Swansea City a crucial win.
Gylfi Sigurdsson's second-half strike from 12 yards looked to have proved the difference in a tight game.
But Rondon bundled in a 92nd-minute equaliser to move the Baggies up to 13th while the Swans drop to 16th.