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Chelsea's grip on the destination of the Premier League title this season loosened a little as Crystal Palace came from behind to win 2-1 at Stamford Bridge.
Having won 10 on-the-bounce on home turf, Antonio Conte's side looked set for another victory when Cesc Fabregas put them ahead after just five minutes, the Spaniard turning home Eden Hazard's cross.
But just four minutes later the Eagles were level, Wilfried Zaha firing home from the edge of the penalty area.
Zaha had a big hand in Palace's second on 11 minutes, this time the winger turned provider with Christian Benteke coolly dinking over Thibaut Courtois.
The hosts piled on the pressure but couldn't find a way past Wayne Hennessy and Sam Allardyce's men had to hold on through 10 minutes of stoppage time to record a famous win.
Tottenham Hotspur are now just seven points behind their London rivals after two second-half goals gave them a crucial win at Burnley.
After a poor first half, Spurs stepped on the gas after the break but struggled to carve their opponents open.
However, the pressure began to tell and on 66 minutes Eric Dier broke the deadlock when he rifled home after the Burnley defence failed to clear Christian Eriksen's set-piece.
Son Heung-ming sealed the win with 13 minutes left on the clock when he tapped in Dele Alli's centre.
The result leaves Sean Dyche's side looking over their shoulder; Mauricio Pochettino will be thrilled with the result but will be sweating on news of the injuries suffered to Harry Winks, Victor Wanyama and Vincent Janssen.
Manchester United's struggle to score goals at Old Trafford continued as they were held to a 0-0 draw by West Brom.
With Ander Herrera, Paul Pogba, Juan Mata and Zlatan Ibrahimovic missing injured or suspended, Marouane Fellaini, Jesse Lingard, Michael Carrick and Henrik Mkhitaryan joined Marcus Rashford and Anthony Martial in forming the front six, but they found the Baggies' defensive structure impossible to breach.
The closest they came was via a Martial header while Fellaini and Mkhitaryan should have done better with chances late on.
Rashford almost produced a stunning winner in the closing stages but Ben Foster produced a brilliant save to stop the forward's 30-yard free-kick.
David de Gea almost gifted the win to Tony Pulis' side when he spilled Darren Fletcher's long-range effort onto the crossbar.
Jose Mourinho's men have now drawn eight league matches at home and lie four points off fourth-placed Manchester City.
Hull City gave themselves a huge boost in their battle to beat the drop as they beat West Ham 2-1 at the KCOM stadium.
Andy Carroll put the Hammers ahead on 18 minutes and they held the advantage until after the break.
The hosts improved in the second period and deservedly equalised through Andrew Robertson on 53 minutes.
Andrea Ranocchia grabbed a priceless winner with five minutes remaining and the result means Marco Silva's side are now only behind 17th-placed Swansea on goal difference, albeit having played a game more.
Leicester City's revival continued as they registered their fourth consecutive league win with a comfortable 2-0 win over Stoke City at the King Power stadium.
Wilfried Ndidi put the Foxes ahead midway through the first half with a lovely strike from distance which gave Lee Grant no chance.
Jamie Vardy doubled the lead on 47 minutes when he volleyed home from close range.
Marko Arnautovic had a goal incorrectly chalked off for Mark Hughes' side while Peter Crouch missed a simple header late on.
Sunderland's fight to stay in the top flight took another blow after they sank to a 1-0 defeat at Watford.
Miguel Britos' 59th-minute header proved the difference for the Hornets while Fabio Borini missed the best opportunity for the Black Cats.
David Moyes' side have now failed to score in five games and are seven points away from safety.
The south-coast derby ended 0-0 as neither Southampton or Bournemouth could find a moment of real quality at St Mary's.
Ireland international midfielder Harry Arter had a chance to win it with 13 minutes left on the clock, but could only succeed in blazing his penalty over the bar, having slipped in his run-up.
Both teams had also hit the woodwork earlier in the tie, with Dusan Tadic curling an effort against the upright for the Saints and Adam Smith driving a shot against the post for the Cherries.
Andrew Surman had an effort cleared off the line for the visitors, while Artur Boruc was forced to palm away a fierce effort from the Saints' Jay Rodriguez.
Liverpool thrashed West Ham 4-1 at the London Stadium to move up to sixth in the Premier League table.
Jose Mourinho has turned down an invitation to meet with a Manchester United fans group after recent critical comments about them.
Peter Crouch climbed off the bench to grab an equaliser and earn Stoke City a 2-2 draw with Leicester City at the Bet365 Stadium.
Ireland manager Martin O'Neill will be without Preston striker Sean Maguire for the World Cup play-off matches against Denmark.
Entertainment was in short supply in the 3pm kick-offs as the four games featured only a combined four goals between them.
West Ham manager Slaven Bilic admitted he faces an uncertain future after a 4-1 home defeat to Liverpool left the club just one point and one place above the dr...
Irish golfer Shane Lowry carded a bogey-free third round 65 to take a share of the lead in the Turkish Airlines Open at the Regnum Carya Golf and Spa Resort.