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Munster, Leinster and Ulster have all made changes for their respective Guinness PRO12 fixtures this weekend.
Ireland flanker Peter O’Mahony is named on the bench for Munster's game with Zebre at Thomond Park tomorrow as he makes his long awaited return from an ACL injury which has kept him out for almost a year.
Lock Darren O'Shea and winger Alex Wotton will both make their first competitive starts for the province, while Simon Zebo returns at full-back after recovering from a rib injury and Tommy O'Donnell comes in at openside flanker after completing return to play protocols for concussion.
Front rowers Duncan Casey and Stephen Archer make their first starts of the season, with Jaco Taute set to make his Munster debut after being named at inside centre.
Donncha Ryan, a late withdrawal from last weekend's win over Edinburgh due to illness, will pack down in the second row with O'Shea.
Meanwhile, Leinster head coach Leo Cullen has made several changes to his starting XV for the trip to face Cardiff Blues tomrrow.
Fergus McFadden returns from injury on the right wing for his first start since the opening day win over Treviso, with Rory O'Loughlin set to make his first competitive start in place of Garry Ringrose at outside centre after making two substitute appearances so far.
Jack McGrath, James Tracy and Mike Ross form a formidable front row, with Mick Kearney joined for his Leinster debut by Ian Nagle at lock.
There are two replacements in the back row with Dan Leavy and Rhys Ruddock coming in at blind side and No. 8 respectively, while Josh van der Flier will start at open side following his two tries against Ospreys last weekend.
Ireland captain Rory Best will make his first start of the season for Ulster in one of eight changes as they welcome Welsh outfit Ospreys to the Kingspan Stadium.
Tommy Bowe could feature for the first time in five months as he is named on the bench.
Best joins Kyle McCall and Rodney Ah You in the front row, with Franco van der Merwe and Alana O'Connor retained in the second row following the impressive win over Glasgow Warriors at Scotstoun last weekend.
The back row of Iain Henderson, Sean Reidy and Roger Wilson are also retained, with Paul Marshall and Paddy Jackson making up an experienced half-back partnership.
Charles Piutau is named at full-back, with the returning Craig Gilroy on the right wing opposite Louis Ludik. Jared payne and Darren Cave are named in the centre.
Munster: Simon Zebo; Darren Sweetnam, Keith Earls, Jaco Taute, Alex Wootton; Tyler Bleyendaal, Conor Murray; Dave Kilcoyne, Duncan Casey, Stephen Archer; Donnacha Ryan, Darren O'Shea; Billy Holland – capt., Tommy O'Donnell, CJ Stander.
Replacements: Niall Scannell, James Cronin, John Ryan, Peter O'Mahony, Conor Oliver, Duncan Williams, Ian Keatley, Cian Bohane.
Leinster: Zane Kirchner, Fergus McFadden, Rory O'Loughlin, Noel Reid, Dave Kearney, Johnny Sexton (Capt), Jamison Gibson-Park; Jack McGrath, James Tracy, Mike Ross, Mick Kearney, Ian Nagle, Dan Leavy, Josh van der Flier, Rhys Ruddock
Replacements: Sean Cronin, Peter Dooley, Michael Bent, Devin Toner, Jamie Heaslip, Nick McCarthy, Joey Carbery, Barry Daly.
Ulster: Charles Piutau, Craig Gilroy, Jared Payne, Darren Cave, Louis Ludik, Paddy Jackson, Paul Marshall; Kyle McCall, Rory Best, Rodney Ah You, Alan O'Connor, Franco van der Merwe, Iain Henderson, Sean Reidy, Roger Wilson
Replacements: J Andrew, C Black, R Kane, K Treadwell, R Diack, Ruan Pienaar, B Herron, Tommy Bowe.
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