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Un De Sceaux will face up to 11 rivals in the Betway Champion Chase on the second day of the Cheltenham Festival.
Trained by Willie Mullins, Un De Sceaux was an impressive winner of the Arkle Trophy at last year's National Hunt Festival and has won two of his three starts this season.
A faller in the Paddy Power Chase, the eight-year-old bounced back to defeat Sire De Grugy at Ascot in January and he is the warm favourite to take the two-mile championship.
Mullins also has Felix Yonger, Twinlight and Vautour, although the latter is expected to run in the Timico Cheltenham Gold Cup on the final day of the Festival.
Sire De Grugy will renew rivalry with Un De Sceaux, while 2013 winner Sprinter Scare looks set to take his chance for Nicky Henderson.
Dodging Bullets landed the Queen Mother 12 months ago and he will bid for back-to-back victories for Paul Nicholls.
Mick Channon has confirmed Somerbsy alongside the Tom George-trained God's Own.
Just Cameron, Sizing Granite and Special Tiara complete the entries.
Former World Hurdle winner More Of That heads the 22 entries still engaged in the RSA Chase.
Jonjo O'Nell's charge has won his two starts over fences and he tops the betting alongside the Gordon Elliott-trained No More Heroes, who has two Grade One victories to his name.
Willie Mullins has eight possibles - Black Hercules, Measureofmydreams, Outlander, Pleasant Company, Pont Alexandre, Roi Des Francs, Sambremont and Shaneshill, while Vyta Du Roc is a possible for Nicky Henderson.
Other possible include Monksland from Noel Meade’s yard and the Mags Mullins-trained Ballychorus.
Mullins also has a strong hand in the Weatherbys Champion Bumper as he bids to race for a ninth time.
The County Carlow handler is responsible for seven of the 25 entries with Augusta Kate, Avenir D'Une Vie, Bacardys, Battleford, Castello Sforza, Turcagua and Very Much So all possible.
First Figaro and Winsome Bucks could represent Dermot Weld, while Jessica Harrington has the option of running New to This Town.