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Manchester United and Liverpool will play each other in the Europa League round of 16.
Liverpool were first out of the pot at Friday's draw in Zurich and as a result Jurgen Klopp's men will host United at Anfield on Thursday, March 10 before the second leg at Old Trafford a week later.
The draw means that at least one Premier League team will be in the quarter-finals, while Tottenham face a tricky tie test against Borussia Dortmund.
United came from behind to beat FC Midtjylland 5-1 on Thursday night, 6-3 on aggregate, while Liverpool progressed after defeating Augsburg.
Former United defender Gary Neville will take his Valencia side to Athletic Bilbao for the first leg with Shakhtar Donetsk drawn at home to Anderlecht and Villareal hosting Bayer Leverkusen. The final two ties see Sparta Prague facing Lazio and Fenerbahce up against Braga.
Europa League round of last-16 draw:
Shakhtar Donetsk v Anderlecht
Basel v Sevilla
Villareal v Bayer Leverkusen
Athletic Bilbao v Valencia
Liverpool v Manchester United
Sparta Prague v Lazio
Borussia Dortmund v Tottenham
Fenerbahce v Braga
Ties to be played March 10 & 17.