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Ireland flanker Josh van der Flier will miss his country's tour of South Africa with an ankle injury that requires surgery.
The 23-year-old sustained the injury in Leinster's Pro 12 match against Ulster on 30 April and underwent an operation that will rule him out for eight weeks.
Van der Flier will also miss Leinster’s Pro12 semi-final against Ulster at the RDS on Friday, 20 May and a subsequent final against Connacht or Glasgow should Leo Cullen's side go through.
The Dubliner, who made his Ireland debut in the 27-10 defeat to England in the Six Nations at Twickenham on 27 February, will also miss the three Tests against the Springboks in Cape Town, Johannesburg and Port Elizabeth in June.
Leinster full-back Rob Kearney (ankle) and out-half Jonathan Sexton (quad) are expected to be fit for the semi-final.
Munster winger Simon Zebo Zebo underwent keyhole surgery on his knee on Tuesday after sustaining an injury during Saturday’s Pro12 win over Scarlets, and will be sidelined "for a number of weeks", putting his participation in Ireland's tour to South Africa in doubt.