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Tottenham defender Jan Vertonghen faces a long spell out after it was confirmed that he has sustained knee ligament damage.
The Belgian international fell awkwardly in a challenge with Crystal Palace attacker Connor Wickham during Tottenham's 3-1 victory over the Eagles.
He was substituted shortly afterwards and was later seen leaving Selhurst Park on crutches.
He underwent a scan on Monday which revealed the extent of the injury and he has now been ruled out for an indefinite period.
"Further assessment & scans have confirmed that @Jan_Vertonghen sustained damage to his medial collateral ligament in his knee at Palace," a tweet from Tottenham revealed.
"Our medical staff will continue to monitor his progress during his rehabilitation to determine when he will be ready to return to training."
Vertonghen has been an ever-present in Mauricio Pochettino's side this season and news of his injury will come as a significant blow to Tottenham's title ambitions.
The north London club currently lie fourth, five points behind leaders Leicester after 23 games.