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Belgium manager Marc Wilmots has confirmed that defender Jan Vertonghen will sidelined for up to eight weeks with the ankle injury he sustained in training this week.
The 29-year-old, who has started all four of Belgium's Euro 2016 fixtures in France this summer, damaged two of his ankle ligaments in training ahead of the Red Devils' quarter-final against Wales in Lille on Friday.
"I blew the whistle to stop the training session and he went down and turned his ankle," Wilmots told a press conference.
"His tournament has come to an end, he'll be out for between six and eight weeks."
Jordan Lukaku is expected to come in at left back with Jason Denayer replacing the suspended Thomas Vermaelen at centre-half.
"I still have a few alternatives to replace Jan.
"I will think it through and we will decide tomorrow."
Wilmots also confirmed that he had been in touch with Vertonghen's club side Tottenham about the injury.
The former Ajax defender will miss Tottenham's opening matches of the Premier League season, which starts on 13 August with a visit to Goodison Park to take on Everton, followed by home matches against Crystal Palace and Liverpool.
Vertonghen missed nine of Tottenham's Premier League games last season because of medial collateral ligament damage in his knee.