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Serena Williams was forced to retire from her third-round match at Indian Wells due to illness.
The former world number one looked in good shape as she won the opening three games but she lost six games on the bounce to lose the first set.
Despite having a lengthy conversation with the trainer and doctor at the end of the opening set, the 37-year-old opted to continue only lose the next game to love.
She walked to her chair and following a conversation with supervisor Donna Kelso she confirmed her retirement
"Before the match I did not feel great and then it just got worse with every second - extreme dizziness and extreme fatigue," the American said.
"By the score it might have looked like I started well, but I was not feeling at all well physically. I will focus on getting better and start preparing for Miami."
Muguruza will play Kiki Bertens in the fourth round.
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Getty Images/Clive Brunskill